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The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α  | The EMBO Journal
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α | The EMBO Journal

The Hypoxia-Inducible Factor Pathway (HIF) | Haase Lab
The Hypoxia-Inducible Factor Pathway (HIF) | Haase Lab

The PHD2:HIF-2α:VHL pathway and EPO gene regulation. Under normoxic... |  Download Scientific Diagram
The PHD2:HIF-2α:VHL pathway and EPO gene regulation. Under normoxic... | Download Scientific Diagram

Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in  the Regulation of Hypoxia-inducible Factor - ScienceDirect
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor - ScienceDirect

Schematic review of PHD2 regulation of the HIF system. Regulation of... |  Download Scientific Diagram
Schematic review of PHD2 regulation of the HIF system. Regulation of... | Download Scientific Diagram

Frontiers | Possible Role of PHD Inhibitors as Hypoxia-Mimicking Agents in  the Maintenance of Neural Stem Cells' Self-Renewal Properties
Frontiers | Possible Role of PHD Inhibitors as Hypoxia-Mimicking Agents in the Maintenance of Neural Stem Cells' Self-Renewal Properties

Role and regulation of prolyl hydroxylase domain proteins | Cell Death &  Differentiation
Role and regulation of prolyl hydroxylase domain proteins | Cell Death & Differentiation

IJMS | Free Full-Text | Structural Characterization of Hypoxia Inducible  Factor α—Prolyl Hydroxylase Domain 2 Interaction through MD  Simulations
IJMS | Free Full-Text | Structural Characterization of Hypoxia Inducible Factor α—Prolyl Hydroxylase Domain 2 Interaction through MD Simulations

Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing  hypoxia-inducible factor-1α | Scientific Reports
Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α | Scientific Reports

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported  non-HIF substrates | eLife
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates | eLife

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and  Contributes to Metabolic Reprogramming via HIF-1α Activation | Scientific  Reports
Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation | Scientific Reports

4 Structural overview of the HIF prolyl hydroxylase PHD2. Views from... |  Download Scientific Diagram
4 Structural overview of the HIF prolyl hydroxylase PHD2. Views from... | Download Scientific Diagram

Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents  Side-Toxicity - ScienceDirect
Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity - ScienceDirect

HIF PHD2 Prodotti CRISPR Knockout e di Attivazione (m) | SCBT - Santa Cruz  Biotechnology
HIF PHD2 Prodotti CRISPR Knockout e di Attivazione (m) | SCBT - Santa Cruz Biotechnology

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and  Contributes to Metabolic Reprogramming via HIF-1α Activation | Scientific  Reports
Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation | Scientific Reports

A) The PHD2:HIF pathway. (Left) Under normoxic conditions, PHD2... |  Download Scientific Diagram
A) The PHD2:HIF pathway. (Left) Under normoxic conditions, PHD2... | Download Scientific Diagram

Regulation of glycolysis by PHD2 is HIF-1α-independent. (A)... | Download  Scientific Diagram
Regulation of glycolysis by PHD2 is HIF-1α-independent. (A)... | Download Scientific Diagram

RCSB PDB - 5L9B: HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH  2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)
RCSB PDB - 5L9B: HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574)

Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial  cells and mice kidney from hypoxia injury | Oncotarget
Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury | Oncotarget

IOX4 is a Highly Selective PHD2 Inhibitor - Immune System Research
IOX4 is a Highly Selective PHD2 Inhibitor - Immune System Research

The HIF-1 pathway. In normoxia, the oxygen-sensing hydroxylases PHD1,... |  Download Scientific Diagram
The HIF-1 pathway. In normoxia, the oxygen-sensing hydroxylases PHD1,... | Download Scientific Diagram

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and  Contributes to Metabolic Reprogramming via HIF-1α Activation | Scientific  Reports
Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation | Scientific Reports

Small-molecule inhibitors of HIF-PHD2: a valid strategy to renal anemia  treatment in clinical therapy - MedChemComm (RSC Publishing)
Small-molecule inhibitors of HIF-PHD2: a valid strategy to renal anemia treatment in clinical therapy - MedChemComm (RSC Publishing)

Regulation of HIF pathway. Under normoxia, PHDs (PHD1, PHD2 and PHD3)... |  Download Scientific Diagram
Regulation of HIF pathway. Under normoxia, PHDs (PHD1, PHD2 and PHD3)... | Download Scientific Diagram

Regulation of HIF-1α by FIH and PHD2 | Download Scientific Diagram
Regulation of HIF-1α by FIH and PHD2 | Download Scientific Diagram

IJMS | Free Full-Text | Structural Characterization of Hypoxia Inducible  Factor α—Prolyl Hydroxylase Domain 2 Interaction through MD  Simulations
IJMS | Free Full-Text | Structural Characterization of Hypoxia Inducible Factor α—Prolyl Hydroxylase Domain 2 Interaction through MD Simulations