Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor
![Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model | Acta Epileptologica | Full Text Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model | Acta Epileptologica | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs42494-021-00054-0/MediaObjects/42494_2021_54_Fig7_HTML.png)
Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model | Acta Epileptologica | Full Text
![PDF] Epithelial–Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1R/IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines | Semantic Scholar PDF] Epithelial–Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1R/IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/c23f93ae50953af4c9f19e953bd7d256df2aa24f/4-Figure1-1.png)
PDF] Epithelial–Mesenchymal Transition Predicts Sensitivity to the Dual IGF-1R/IR Inhibitor OSI-906 in Hepatocellular Carcinoma Cell Lines | Semantic Scholar
![IJMS | Free Full-Text | Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage IJMS | Free Full-Text | Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage](https://pub.mdpi-res.com/ijms/ijms-22-05706/article_deploy/html/images/ijms-22-05706-g001.png?1622106338)
IJMS | Free Full-Text | Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage
![IJMS | Free Full-Text | Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage IJMS | Free Full-Text | Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage](https://www.mdpi.com/ijms/ijms-22-05706/article_deploy/html/images/ijms-22-05706-g002-550.jpg)
IJMS | Free Full-Text | Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage
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Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway | Diabetologia
![Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model | Acta Epileptologica | Full Text Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model | Acta Epileptologica | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs42494-021-00054-0/MediaObjects/42494_2021_54_Fig3_HTML.png)
Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model | Acta Epileptologica | Full Text
![Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model | Acta Epileptologica | Full Text Linsitinib (OSI-906) modulates brain energy metabolism and seizure activity in the lithium-pilocarpine rat model | Acta Epileptologica | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs42494-021-00054-0/MediaObjects/42494_2021_54_Fig2_HTML.png)